Wedgewood Pharmacy

405 Heron Drive Suite 200
Swedesboro, NJ 08085
Ph 800.331.8272
www.wedgewoodpetrx.com
Questions?  Call 1-877-357-9661

Ophthalmic Medications

Veterinary: Order Online Now
Pet Owners: Pick Up and Fill a New Prescription

by George J. Malmberg, RPh, FACA

Basic Information

Compounded ophthalmic formulations for veterinary patients are used more often than ever before.Prepared in a dedicated cleanroom according to strict regulations for sterile compounds, their ingredients, strength and dosage form can be individualized to treat the diseased or injured eye. Common ocular diseases treated with compounded medications include:

  • Canine keratoconjunctivitis
  • Canine chronic superficial keratitis (pannus)
  • Canine topic blepharoconjunctivitis
  • Canine glaucoma
  • Feline herpetic keratitis
  • Conjunctivitis and viral ophthalmic conditions in a variety of species
  • Equine keratomycosis
  • Ocular manifestations of Bartonella henselae in cats

Although most compounds used to treat ophthalmic disease in veterinary patients are applied topically, compounded oral medications also are prescribed.

When to Prescribe Compounded Ophthalmic Medications

Veterinary practitioners diagnose and treat numerous ophthalmic conditions. More difficult cases usually are referred to a veterinary ophthalmologist for treatment. Most veterinary ophthalmologists are members of the American College of Veterinary Ophthalmologists or the American Society of Veterinary Ophthalmologists.

Compounded medications are prescribed when:

  • The best therapy for a patient is not commercially available.
  • The active drug ingredient is not available in the desired strength or dosage form.
  • A commercial product is on extended backorder.
  • A commercial product has been discontinued by the manufacturer for non safety reasons.
  • Patient/owner compliance may be improved and stress reduced through the use of pet friendly flavoring and alternative dosage forms, resulting in better patient outcomes.
  • A new therapy reported in the veterinary literature is not available commercially.
  • Special flavorings are required for oral medications.
  • Dye free or preservative free topical formulations are necessary.

Effective Dosage Forms

The most common dosage forms for topical veterinary ophthalmic medications are solutions, suspensions, ointments and gels. These dosage forms are all within the capability of a knowledgeable compounding pharmacist with the appropriate equipment (discussed under Due Diligence ). Each dosage form has unique formulation considerations.

Ophthalmic Solutionsare one of the most frequently used dosage forms. Considerations when formulating a solution include solubility of the formula ingredients, clarity, tonicity, buffers, pH, sterility and appropriate selection of preservatives when indicated. The most common vehicle for solutions is water; however, there are oil solutions of select chemicals.

Ophthalmic Suspensionsgenerally are prescribed for medications that are not water soluble. They usually are aqueous suspensions of the active ingredient. Particle size and the selection of a suspending agent are important when compounding an ophthalmic suspension. The particles in the suspensions must be small and uniformly suspended after shaking. Additional considerations are pH, sterility and preservatives.

Ophthalmic Ointments and Gelsare solid dosage forms using either the more common white petrolatum vehicle or the newer aqueous methylcellulose gel. Compounding considerations for gels include ensuring a small, uniform particle size for a non gritty, non irritating product. Additionally, sterility and the selection of a preservative, if needed, must be considered.

All dosage forms then must be packaged in an appropriate container. The packaging of veterinary ophthalmics must be sterile, protect the active drug and facilitate administration. There are a number of options available including amber glass dropper bottles or an opaque plastic drop container to dispense solutions, and suspensions and tubes with ophthalmic applicator tips for ointments and gels.

Due Diligence Considerations

Not every pharmacy has the equipment, qualified staff or facilities necessary to perform sterile compounding. The veterinarian who prescribes any preparation bears responsibility for the outcome of treatment and must exercise due diligence in selecting a compounding pharmacy. At a minimum, the pharmacy should have a Class 1000 cleanroom with a Class 100 Laminar Air Floor Hood or a Glovebox/Isolator to provide a sterile environment. This equipment should be certified independently biannually. Additional equipment such as sterilization filters, pH meters, micronizers, autoclaves and ointment mills also are used by the pharmacist to prepare quality pharmaceutical preparations. Pharmacists should be familiar with veterinary compounding in general and veterinary ophthalmic compounding in particular. Compounding personnel should be trained and validated in aseptic technique according to USP guidelines. Quality control evaluations that include weight, volume, pH, visual inspection, post filtration integrity testing and sterility testing should be performed on all batches of ophthalmic preparations. Documentation should be extensive and allow for the tracing of any dispensed medication back to the formulation worksheet and ingredient lot number. After the above criteria are met, other factors such as turnaround time and quality customer service, membership in professional organizations such as the American College of Veterinary Pharmacists and attendance at veterinary ophthalmology meetings also should be considered when a compounding pharmacy is selected to prepare ophthalmic preparations.

Compounded medications offer an excellent alternative for many ophthalmic patients.


The information contained on this site is general in nature and is intended for use as an informational aid. It does not cover all possible uses, actions, precautions, side effects, or interactions of the products shown, nor is the information intended as medical advice or diagnosis for individual health problems or for making an evaluation as to the risks and benefits of using a particular product. You should consult your doctor about diagnosis and treatment of any health problems. Information and statements have not been evaluated by the Food and Drug Administration ("FDA"), nor has the FDA approved the products to diagnose, cure or prevent disease.

Wedgewood Pharmacy's compounded veterinary preparations are not intended for use in food and food-producing animals.
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